RIME 200

RIME 200

Cefixime (200 mg), Lactic Acid Bacillus (60 m.s.)

Cefixime is an oral third-generation cephalosporin antibiotic. It is used to treat gonorrhea, tonsillitis, and pharyngitis. The usual dose is 400 mg in two divided doses for 5–7 days.

Some people use Bacillus coagulants to prevent respiratory infections and ramp up the immune system. It is also used to prevent cancer or to manufacture cancer-causing agents. There is also some interest in using vaccines as an additive to improve their effectiveness. Lactic acid bacillus is dormant bacteria that are good for the intestine. It helps in treating bacterial infections. They inhibit the growth of other pathogenic bacteria that cause diarrhea or other bacterial infections.



Mechanism of Action:

Cefixime binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, thereby inhibiting the third and final phase of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; cefixime may interfere with an autolysin inhibitor.

Pharmacokinetic Properties:

Cefixime binds one or more of the penicillin-binding proteins (PBPs) that inhibit the final transpeptidation step of peptidoglycan synthesis in the bacterial cell wall, thus inhibiting biosynthesis and inhibiting cell wall assembly that results in the death of bacterial cells.

  • Absorption: Only 40–50% is absorbed by the GI tract (oral); The rate may decrease when taken with food. More absorption from oral suspension than tablets.
  • Delivery: Bile, urine (high concentration); Crosses the placenta. Protein-binding: 65%.
  • Excretion: 20% of an oral dose excreted through the urine unchanged; 60% non-elimination; Some of the bile is excreted through the feces. Largely removed by dialysis.

Drug-Drug interactions:

Although some drugs should not be used together, in other cases two different drugs may be used together, even though an interaction may occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your health care professional knows if you are taking any of the medicines listed below. The following interactions have been chosen based on their potential importance and are not necessarily all inclusive.

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.


History of allergy to penicillins; pregnancy, lactation; renal failure; GI disease.

Should be taken with food.


Rime Tablet is safe to use during breastfeeding. Human studies show that the drug does not infuse a significant amount of breastmilk and is not harmful to the child.


Animal studies have failed to reveal evidence of fetal loss or impaired fertility up to 400 times the recommended dose of humans; However, the incidence of miscarriage was increased at levels reaching maternal toxicity. There are no controlled data in human pregnancy.


Adult: PO- Hypersensitivity infection- Recommended dose is 200-400 mg / day.

Uninfected gonorrhea – The recommended dose is 400 mg as a single dose.

Duration of action:

Extreme serum levels in about 4 hours.

The half-life is approximately 3 to 4 hours and is not dose-dependent. Cefixime is excreted by the kidneys. Approximately 50% of the absorbed dose is unchanged in the urine after twenty-four hours. There is no evidence of the metabolism of cefixime in vivo.

Adverse Reaction:

Adverse drug reactions include diarrhea, indigestion, nausea, and vomiting. Hypersensitivity reactions such as skin rashes, hives, and Stevens-Johnson syndrome have been reported. Although thrombocytopenia has been reported for many cephalosporins, it has not been reported for syphixime. There is no specific antidote for Cefixime overdose. Gastric lavage may be performed. Dialysis will not remove significant amounts of Cefixime.


Store it at room temperature and in an airtight container. Keep away from children.


Gastric lavage may be indicated; Otherwise, no specific antidote exists. Significant amounts of Cefixime are not removed from circulation by hemodialysis or peritoneal dialysis. Adverse reactions to small numbers of healthy adult volunteers receiving cefixes of up to 2 grams did not differ from the profile observed in patients treated at the recommended doses.


Pseudomembranous colitis, thrombocytopenia, thrombophlebitis, leukopenia, seizures, flatulence, dizziness, headache, nausea, vomiting, anorexia, diarrhea, abdominal pain, urticaria, pruritus, dyspepsia, hypersensitivity.


To make sure that cefixime is safe for you, tell your doctor if you are allergic to any drugs, especially penicillin.

Chewable tablet form may contain phenylalanine. If you have phenylketonuria (PKU), talk to your doctor before using this medicine.

It is not known whether this drug will harm an unborn child. Tell your doctor if you are pregnant.

It is not known whether cefixime passes into breast milk or if it can harm a nursing baby. Tell your doctor if you are breastfeeding. You may need to stop nursing while you are taking Cefixime.

Cefixime suspension (liquid) contains sucrose. If you have diabetes, talk to your doctor before using this kind of cefixime.


It is not known whether this drug will harm an unborn child. Tell your doctor if you are pregnant.