CYROX
Pharmacology of Drug -Roxithromycin
Mechanism of Action
Roxithromycin is a semi synthetic long acting macrolide antibiotic. It binds to the 50S sub unit of bacterial ribosome and inhibits translocation.ie: they interfere with the transfer of the newly formed peptide chain from the A site to the P site and fails to expose the A site .So that A site is unable to bind with the next aminoacyl t RNA complex. This leads to premature termination of amino acid chain and there by inhibits protein synthesis.
Pharmaco Kinetics
Absorption: Roxithromycin is absorbed after oral administration. Distribution: It is widely distributed in the body in protein bound form. Metabolism: small portion undergo metabolism. Excretion: It is primarily excreted through bile and also excreted through urine and breast milk
Onset Of Action 1 – 2 hours
Duration Of Action 8 – 12 hours
Adverse Effects
1. Nausea 2. Vomiting 3. Diarrhoea 4. Epigastric pain 5. Fever 6. Rash 7. Urticaria 8. Increase in liver enzyme concentrations
ContraIndications
1. Hypersensitivity to Roxithromycin and other macrolide 2. Use of ergotamine type compound along with Roxithromycin
Special Precautions
1. Hepatic dysfunction
Pregnancy
Use with caution
Breast Feeding
Use with caution
Old Age
May be used
Interactions
Digoxin: Increases absorption. Midazolam: Increases its half-life. Terfenadine: Serum levels elevated leading to ventricular arrhythmias. Disopyramide: Displaced from its protein bound sites.
Indications
1. Pneumonia 2. Tonsilitis 3. Pharyngitis 4. Bronchitis 5. ENT infection 6. Tetanus 7. Diphtheria 8. Sinusitis 9. Gonorrhea 10. Wound and burn infection 11. Skin and soft tissue infections 12. Pertusis 13. Urogenital infection
Dosage
Adult: 300 mg in two divided dose for 1 – 2 week Children: 4 – 8 mg/kg body weight/day in divided dose
Schedule H
Storage
Store in a cool dark place. Keep away from heat and moisture.
Over Dose
Give supportive measures and treatment