Pharmacology of Drug -Trifluoperazine + Chlordiazepoxide

Anti-psychotics as a therapeutic class include the following :

I.PHENOTHIAZINES These include Chlorpromazine, Oxycarbazine, Promazine, Triflupromazine, Thioridazine, Prochlorperazine, Fluphenazine & Trifluoperazine. M.O.A.: It is postulated that they cause their effects by blocking dopamine receptors in CNS. Depending on to the drug used other pharmacological actions seen in varying degrees include cholinergic, adrenergic, histaminergic and serotonergic blocking activity. The exact mechanism of their action is unknown.

When administered to normal person these drugs cause emotional quietening, indifference to surroundings and sedation. When given in psychotics they decrease agitation, aggressiveness and tend to bring behaviour towards normality. Their administration may cause movement disorders.

II.OTHER HETEROCYCLIC COMPOUNDS Butyrophenone : Haloperidol Dibenzoxazepine : Loxapine Dibenzodiazepine :Clozapine Benzisoxazole : Risperidone Diphenylbutylpiperidine : Pimozide. III.MISCELLANEOUS Penfluridol, Flupenthixol and Trifluoperidol. Antimanic drugs include Lithium. Equivalent doses of oral antipsychotics Antipsychotic Daily dose Chlorpromazine 100mg Clozapine 50mg Haloperidol 2-3mg Loxapine 10-20mg Pimozide 2mg Risperidone 0.5-1mg Thioridazine 100mg Trifluoperazine 5mg These equivalences are intended only as an approximate guide. In specialised psychiatric units, equivalent dose of Haloperidol may be upto 10mg.