RIME – 100DT

RIME 100DT

Cefixime:

Cefixime is an oral third generation cephalosporin antibiotic. It is used to treat gonorrhea, tonsilitis, and pharyngitis. The usual dose is 400 mg in two divided doses for up to 5-7 days.

Mechanism of Action:

Cefixime binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefixime interferes with an autolysin inhibitor.

Pharmacokinetics:

Cefixime binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Absorption
Only 40-50% is absorbed from the GI tract (oral); rate may be decreased if taken with food. Greater absorption from oral suspension than tablets.
Distribution
Bile, urine (high concentrations); crosses the placenta. Protein-binding: 65%.
Excretion
20% of an oral dose excreted via urine unchanged; 60% nonrenal elimination; some is excreted via the faeces from the bile. Substantially removed by dialysis.

Side Effects:

Pseudomembranous colitis, thrombocytopenia, thrombophlebitis, leucopenia, seizures, flatulence, dizziness, headache, nausea, vomiting, anorexia, diarrhea, abdominal pain, urticaria, pruritus, dyspepsia, hypersensitivity.

Drug Interaction:

Probenecid may increase the blood concentration of cefixime by decreasing removal of cefixime by the kidney. May increase prothrombin time with anticoagulants.

Cefixime is an oral third generation cephalosporin antibiotic. It is used to treat gonorrhea, tonsilitis, and pharyngitis. The usual dose is 400 mg in two divided doses for up to 5-7 days.

Dosage & When it is to be taken :

Adult: PO- Susceptible infections- The recommended dose is 200-400 mg/day.
Uncomplicated gonorrhoea- The recommended dose is 400 mg as a single dose.

Special Precautions:

History of allergy to penicillins; pregnancy, lactation; renal failure; GI disease.

Should be taken with food.

Storage:

Store it at room temperature and in an airtight container. Keep away from children.