Ofloxacin (200 mg), Ornidazole (500 mg)
Cyflox OZ Tablet is a combination of two antibiotics firstly is Ofloxacin 200g and the secondly is Ornidazole 500 mg that conclusively kills the microorganisms. It cures by gynecological infections, lung infections, urinary infections, and gastrointestinal infections such as acute diarrhea or dysentery. If you experience any allergic reaction like rashes, itching, swelling, shortness of breath, etc, you should consult the doctor immediately.
Ofloxacin is a quinolone antibiotic for treating bacterial infections. When taken by mouth or injection into a vein, these include pneumonia, cellulitis, urinary tract infections, prostatitis, plague, and certain types of infectious diarrhea.
Ornidazole is an antibiotic used to treat protozoan infections. A synthetic nitroimidazole is commercially obtained from an acid-catalyzed reaction between 2-methyl-5-nitroimidazole and epichlorohydrin.
Mechanism of Action :
Ofloxacin is a bactericidal drug. It acts by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three-dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil into the DNA double helix. Ofloxacin inhibits DNA gyrase which results in the abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired. This will inhibit transcription of DNA into RNA and subsequent protein synthesis
The onset of Action: Within 0.5 hour
Half-Life: 5 – 8 hours
Duration of Action: 12 – 16 hour
This medication is an antiamoebic agent, prescribed for amoebic dysentery.
Absorption: Ofloxacin is rapidly and completely absorbed after oral administration. Distribution: It is widely distributed in the body. Metabolism: It undergoes insignificant metabolism. Excretion: The drug is excreted mainly through urine.
Oral Anticoagulants: The effects of oral anticoagulants, may be increased. Theophylline: Increased plasma levels of theophylline resulting in toxicity. NSAID`s: CNS excitation may occur.
1. Hepatic impairment 2. Renal impairment 3. Cerebral arteriosclerosis 4. Epilepsy 5. CNS disease 6. Avoid exposure to sunlight 7. Caution while driving the vehicle or operating machine or involved in any hazardous activities.
If you are pregnant or breastfeeding, think if you can become pregnant or are not planning to have a baby. If you become pregnant while taking Ofloxacin, stop taking the pills and contact your doctor immediately.
Adult- The recommended dose range is 0.5gm to 1.5gm daily for 1 to 7 days.
Duration of action:
12 – 16 hours
1. Nausea 2. Vomiting 3. Diarrhea 4. Abdominal discomfort 5. Constipation 6. Dry mouth 7. Dizziness 8. Headache 9. Rash 10. Pruritis 11. Pseudomembranous colitis 12. Visual disturbances 13. Insomnia
Store at 15 – 30 degrees C in a tightly closed container.
Give supportive measures and symptomatic treatment. Gastric lavage has to be done
Hypersensitivity to Ofloxacin and other Fluoroquinolones
1. Hepatic impairment 2. Renal impairment 3. Cerebral arteriosclerosis 4. Epilepsy 5. CNS disease 6. Avoid exposure to sunlight 7. Caution while driving the vehicle or operating machine or involved in any hazardous activities
Side Effects: Central Nervous System- Drowsiness, dizziness, headache, tremor, rigidity, poor coordination, epilepsy, tiredness, temporary loss of consciousness, and fainting.
Miscellaneous- Nausea, vomiting, taste disturbances, liver impairment, skin reactions like rash, itching, and inflammation.
Fluoroquinolones have been associated with disabling and potentially irreversible serious adverse reactions that have occurred together including tendinitis and tendon rupture, peripheral neuropathy, and central nervous system (CNS) effects.
Old Age: Use with caution