CYNAGRA 100

CYNAGRA 100

 Sildenafil Citrate (100 mg)

Cynagra 100mg Tablet is a medication used to treat erectile dysfunction in men. It helps the man to increase blood flow to the penis and achieve or maintain erections. It parts to a group of medicines known as phosphodiesterase type 5 (PDE5) inhibitors.

Sildenafil (generic Viagra) is a drug used to treat erectile dysfunction and pulmonary arterial hypertension. It is not clear whether it is effective for the treatment of sexual dysfunction in women. It is carried into the vein by mouth or injection.

 

Mechanism of Action

Sildenafil is a phosphodiesterase enzyme (PDE5) inhibitor. This enzyme is responsible for the degradation of cyclic guanosine monophosphate (cGMP) produced in response to sexual stimulation. The more cGMP available, the more durable the construction. Sildenafil inhibits the PDE5 enzyme, preserving cGMP levels, therefore supporting erectile viability and durability due to the filling of the penis with penile blood. Filling occurs because the blood vessels that carry blood to the penis increase in size and carry more blood to the penis and at the same time, the blood vessels that carry blood from the penis decrease in size and draw less blood from the penis. Sexual stimulation that leads to an erection causes the production and release of nitric oxide in the corpora cavernosa of the penis.

Nitric oxide causes an enzyme guanylate cyclase, to produce cyclic guanosine monophosphate (cGMP). It is cGMP that is primarily responsible for moving and enlarging blood vessels from the penis to the penis and causes erection respectively. When cGMP is destroyed by the enzyme phosphodiesterase-5, the blood vessels return to their normal size, the blood leaves the penis, and the erection ceases. Sildenafil inhibits phosphodiesterase-5 by destroying cGMP so that cGMP will last longer. The persistence of cGMP leads to prolonged bulging of the penis with blood. It relaxes the muscles and increases the flow of blood to particular areas of the body.

Onset Of Action Within 30 minutes

Half-Life 4 hours

Indications

Erectile dysfunction

Pharmacokinetic Properties:

Absorption: It is easily absorbed by the bloodstream and bioavailability is about 40%. Distribution: It is widely distributed in tissues in a protein-bound form (96% bound to plasma proteins). Metabolism: It is metabolized in the liver, known as CYP3A4, and other enzymes that produce active N-desmethyl derivatives. Excretion: It is excreted mainly in small amounts in feces (80%) and urine.

Drug-Drug interactions:

Non-specific beta-blockers, loops, and potassium-sparing diuretics increase the efficacy of sildenafil. Concomitant administration of sildenafil 100mg and amlodipine 5 or 10mg in hypertensive patients led to a decrease in blood pressure by the addition of 8 mm Hg systolic and 7 mm Hg diastolic. Psychochrome P450 inhibitors such as erythromycin, ketoconazole, itraconazole are likely to reduce sildenafil withdrawal.

Precautions:

1. Do not take sildenafil more than once a day. If erectile pain is painful, contact a doctor or stay for more than 4 hours. Heart disease 4. Recent history of heart attack (within last 90 days) 5. Recent history of stroke or heart failure (within last 6 months) 11. Sickle cell anemia 12. Multiple myeloma 13. Leukemia 14. Haemophilia 15. Stomach ulcer 16. Retinitis pigmentosa 17. Peyronie’s disease (a physical deformity of penis) 18. Diabetes 19. High cholesterol 20. Pre-existing eye problems 21. Those who smoke or are over 50 years old

Breastfeeding: Contraindicated

Fertility:

Sildenafil had no statistically significant effect on sperm motility, count, or density; Percentage of abnormal sperm forms; Or the percentage of living sperm. It also did not affect the ejaculation volume or viscosity. All measures were within normal limits

Dosage: 

Adult: Taken 50 mg, 1 hour before sexual activity or anywhere from 0.5 – 4 hours before sexual activity. Depending on the effectiveness and inclination, the dose may be increased to a maximum of 100 mg or reduced to 25 mg. The maximum recommended dosage frequency is once per day.

Duration of action: 

4 hours

Adverse Reaction:

1. Facial flushing 2. Headache 3. Upset stomach 4. Diarrhea. Flu-like symptoms 6. Nausea 7. Backache. 8. Muscle aches. Low blood pressure 10. Dim vision 11. Abnormal ejaculation 12. Prolong wear 13. Sweating 14. General feeling sick 15. Irregular heartbeat 16. Swelling of hands, ankles, or feet. 17. Shortness of breath. 18. Lighthouse 19. Fainting in pre-existing heart disease: 1. Chest pain 2. Heart attack/death 4. . Stroke 5. Increase in heart rate and heart rate 6. Vision change

Storage:

Store at room temperature between 15-30°C. Protect from moisture and heat. Keep out of the reach of children.

Overdosage:

No overdose, if any overdose occurs then seeks immediate medical attention. Give supportive measures and symptomatic treatment.

Contraindictions:

1. Hypersensitivity to Sildenafil 2. Patients on nitrate therapy 3. Patients taking an adrenergic receptor antagonist

Warnings:

Sildenafil can cause a severe allergic reaction. Symptoms may include:

Shortness of breath, swelling in your throat or tongue

If you ever had an allergy to it, do not take this medicine again. Taking it again can be fatal (cause of death).

The use of beverages that contain alcohol makes you at risk of low blood pressure from sildenafil. If you drink alcohol, talk to a doctor.

Pregnancy: Contraindicated

Old Age: Use with caution

Children: Contraindicated

NEONATES: Contraindicated