LEVOCYN – A

LEVOCYN A

Levocetirizine hydrochloride (5 mg), Ambroxol Hydrochloride (60 mg)

Levocetirizine hydrochloride, an antihistamine, is a major metabolite of hydroxyzine and is a rectomic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioclema, and urticaria. The structural similarity of levocetirizine to hydroviazine, and its derivatization from piperazine, has been shown to characterize adverse reactions and properties similar to other piperazine derivatives.

Ambroxol is indicated in “bronchopulmonary therapy with abnormal mucus secretion and impaired mucus transport. It promotes mucus clearance, facilitates expectoration, and reduces productive cough, allowing the patient to independently And breathe deeply.

 

Mechanism of Action:

Levocyn-A (Cetirizine / Ambroxol) treats allergies by blocking histamine receptors and breakdown down mucus. It is produced by combining antihistamines with a systemic mucolytic agent. Cetirizine is classified as a second-generation antihistamine. It works by selectively inhibiting H1 histamine receptors. By preventing histamine from acting on its receptors, this drug helps reduce symptoms caused by hay fever or other allergies (such as a runny nose and watery eyes). Ambroxol has secretolytic properties, and it works by reducing the viscosity (thickness) of mucus, allowing it to remove more from the body.

Pharmacokinetic Properties:

Recently the pharmacokinetics of ambroxol have been reviewed in detail in Cazan et al. Ambroxol has a bioavailability of 79% when given orally. It is metabolized in the liver by cytochrome P450 3A4 and has an elimination half-life of approximately 10 h of terminal 10, with a total clearance of 660 ml / min. Upon delivery of blood from the tissue, the highest concentration of ambroxol is found in the lungs; In human lung tissue, ambroxol has been found in 15- to 20-fold higher concentrations present in the blood. Furthermore, age and sex have not been shown to affect the pharmacokinetics of ambroxol to a clinically relevant extent, so dose adjustment is not indicated.

Drug-Drug interactions:

Increased INR and risk of epistaxis when taken together with warfarin.

Potentially fatal: CNS depressant and anticholinergics may potentiate CNT depressant cetirizine.

Precautions:

1. If you have an allergic or hypersensitive reaction, seek emergency medical attention.

2. Possible symptoms include difficulty breathing, difficulty swallowing, swelling, chest tightness, skin rashes, and hives.

3. Use of this medicine should only be prescribed and prescribed by your doctor or pharmacist. Do not change your dose unless specifically instructed to do both of the above.

4. Dose and use often depend on the severity of the condition, as well as the patient’s medical history and current health status.

5. Before you start using this medicine, make sure that your doctor is aware of the following:

If you are pregnant or breastfeeding.

If you have any allergies.

If you have any other disease, disorder, or medical conditions.

If you are using any other medicines or medicines.

If you are using any vitamin or supplement.

Fertility:

For levocetirizine no clinical data are available

Dosage:

Levocyn-A (Cetirizine / Ambroxol) tablet is filmed and contains 5mg cetirizine and 60mg ambroxol. Your doctor will assess the severity of your symptoms when deciding on the correct dosage. After this, a dose can be prescribed to suit your individual needs. Always follow the dosing instructions given by your doctor and do not take more than the recommended dosage as it may endanger your health and safety.

Duration of action:

After oral administration of a dose of 5 mg of Levocetirizine dihydrochloride oral solution for healthy adult subjects, mean peak plasma concentrations were achieved at approximately 0.5 hours post-dose.

Adverse Reaction:

Drowsiness, fatigue, and dry mouth may occur. Fever or cough may also occur, especially in children. If any of these effects persist or worsen, tell your doctor or pharmacist immediately.

Storage:

Oral: Store at 20-25°C.

Overdosage:

Do not overdose. If someone takes too much something serious can happen, immediately go to the doctor.

Contraindictions:

Those patients with a known hypersensitivity to it or its parent compound, hydroxyzine.

Side effects

Patients treating allergies or any other medical conditions with the medicine. Levocyn-A (Cetirizine/Ambroxol) may experience some side effects. Contact your physician if this happens. Some examples are listed here:

  • Headache
  • Digestive upset
  • The dry feeling inside the mouth
  • Discomfort affecting the throat
  • Feelings of fatigue or somnolence

Although the occurrence of serious side effects is not considered to be common, patients still need to make themselves aware of the fact that this may occur in rare cases. Attend the emergency room or consult your physician straight away if you notice abnormally hyperactive behavior, shaking visual disturbances, or any other serious side effects that have not been listed here.

Warnings:

This drug contains levocetirizine. If you are allergic to levocetirizine or any of the ingredients contained in this medicine, do not take Zial Allergy 24HR Tablet, Zia Allergy 24HR Oral Solution, or Ziyazal.

Keep out of reach of children. In case of an overdose, seek medical attention or contact a toxin control center immediately.

Pregnancy

Contraindicated; since Cetrizine and Ambroxol are contraindicated in pregnancy; the combination generic are contraindicated in pregnancy.

Breast Feeding

Contraindicated; since Cetrizine and Ambroxol are contraindicated in breastfeeding; the combination generic is contraindicated in breastfeeding mothers.