CYNAC

CYNAC

Aceclofenac (100 mg)

Aceclofenac is a non steroidal antiinflammatory drug (NSAID) analog of Diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. The dose is 100 mg twice daily.

It should not be given to people with porphyria or breast-feeding mothers and is not recommended for children.

Mechanism Of Action: Aceclofenac has a higher anti-inflammatory action than conventional NSAIDs. It is a cytokine inhibitor. Aceclofenac works by inhibiting the action of any substance in the body called cyclo-oxygenase. Cyclo-oxygenase is involved in the production of prostaglandins (chemicals in the body) that cause pain, swelling, and inflammation. Aceclofenac is the glycolic acid ester of diclofenac.

Half-Life of Aceclofenac

The mean plasma elimination half-life is 4 – 4.3 hours

Indications for Aceclofenac

1. Ankylosing spondylitis

2. Osteoarthritis

3. Symptomatic treatment of pain and inflammation in Post-Traumatic pain

4. Cervical pain

5. Low back pain

6. Acute gout

Pharmacokinetic Properties:

Absorption – It is rapidly and completely absorbed after oral administration.

Distribution- Widely distributed in the body in protein-form. It is highly protein-bound (> 99.7%). Aceclofenac penetrates the synovial fluid, where concentrations reach about 60% in plasma.

Metabolism- Metabolites in the liver cause metabolism. The main metabolite is 4-hydroxycyclofenac.

Excretion – It is mainly excreted through urine in the form of conjugated hydroxymetabytes.

Drug-Drug interactions:

Lithium, digoxin, and methotrexate: Aceclofenac may increase plasma concentrations of lithium, digoxin, and methotrexate.

Anticoagulants: The activity of anticoagulants may increase.

Diuretics: Aceclofenac inhibits the activity of diuretics. When potassium is administered concomitantly with sparing diuretics, serum potassium should be monitored.

Cyclosporine: Aceclofenac cyclosporine may increase nephrotoxicity.

Quinolones: Aceclofenac can exacerbate spasms when coadministered with quinolone antibiotics.

Precautions:

Hepatic porphyria, Bleeding tendencies, Blood disorders, Crohn`s disease, Decreased heart function, History of peptic ulcers, Inflammation of the bowel and back passage, Mildly decreased kidney function, Recent major surgery, Stomach disorders, Decreased liver function, Intestinal disorders

Breastfeeding: Contraindicated.

Fertility:

The use of Aceclofenac can impair female fertility and is not recommended in women who try to conceive. Women who have difficulties in conceiving or who are undergoing infertility testing should take Aceclofenac 100 mg film-coated tablets.

Dosage:

 

Take the missed dose as soon as you remember. If it is time for your next dose, skip the missed dose. Do not double your dose for a missed one.

Seek emergency medical treatment or contact a doctor in case of an overdose.

Duration of action:

The medicine shows its results within 1.5 to 3 hours and its effect lasts for 12 to 16 hours.

Adverse Reaction:

Indigestion – including abdominal pain, feeling sick, and diarrhea.

Stomach ulcers – can cause internal bleeding and anemia; Additional medication to protect your stomach may be prescribed to help reduce this risk.

Headache.

Drowsiness.

Dizziness.

Allergies

Storage:

 This medicinal product does not require any special storage conditions.

Overdosage:

Management of acute toxicity with NSAIDs essentially involves supportive and symptomatic measures.

a) symptoms

Symptoms include headache, nausea, vomiting, epigastric pain, gastrointestinal irritation, gastrointestinal bleeding, rarely diarrhea, disorientation, excitement, coma, drowsiness, dizziness, tinnitus, hypotension, respiratory depression, fainting, occasional convulsions. . Acute renal failure and liver damage are possible in cases of significant toxicity.

B) therapeutic measures

Patients should be treated as needed.

Within an hour of ingestion of a potentially toxic amount, activated charcoal should be considered. Alternatively, in adults, gastric lavage should be considered within one hour of ingestion of a potentially life-threatening overdose.

Contradictions:

1. Hypersensitivity to the drug

2. Bleeding from the stomach or intestines

3. Moderate to severely decreased kidney function

4. Hypersensitivity to other NSAIDs

5. Active peptic ulcer

 

Side Effects of Aceclofenac:

Dyspepsia, Abdominal pain, Dizziness, Vertigo, Pruritis, Rash, Dermatitis, Nausea, Diarrhoea, Flatulence, Gastritis, Constipation, Vomiting, Ulcerative stomatitis, Elevation of circulating levels of hepatic enzymes.

Warnings:

 

This medicine should be used with caution in the elderly due to the increased risk of serious adverse effects. Treatment with this medicine should be started at low doses to check for tolerance. Depending on the clinical condition, close monitoring of renal and liver function may be necessary for such patients.

This medicine is not recommended for use in patients under 18 years of age as the safety and efficacy of the use are not clinically established.

Pregnancy: Contraindicated.

Children Related Information: Use with caution