LECOURSE – 500

LECOURSE 500

Pharmacology of Drug -Levofloxacin

Mechanism of Action
Levofloxacin is a broad spectrum antibacterial agent. It act by inhibiting the enzyme DNA gyrase (Topoisomerase 2) and Topoisomerase 4.DNA gyrase helps in the formation of a highly condensed three dimensional structure of the DNA by its nicking and closing activity and also by introducing negative supercoil in to the DNA double helix. Levofloxacin inhibits DNA gyrase which results in abnormal linkage between opened DNA and gyrase and negative supercoiling is also impaired. This will inhibits transcription of DNA in to RNA and subsequent protein synthesis.

Pharmaco Kinetics
Absorption: It is rapidly and completely absorbed after oral administration. Distribution: It is distributed widely in the body. Metabolism: It undergoes insignificant metabolism in the liver. Excretion: Drug is excreted mainly through urine.

Half Life
6 – 8 hour

Half Life Adverse Effects
1. Nausea 2. Vomiting 3. Diarrhoea 4. Abdominal discomfort 5. Restlessness 6. Dizziness 7. Drowsiness 8. Arthralgia 9. Rash 10. Confusion 11. Insomnia 12. Anorexia 13. Bad taste 14. Headache 15. Photosensitivity.

ContraIndications
Hypersensitivity to Levofloxacin and other Fluoroquinolones

Special Precautions
1.Hepatic impairment 2.Renal impairment 3.Epilepsy 4.Cerebral arteriosclerosis 5. Caution while driving the vehicle or operating machine or involved in any hazardous activities. 6. Avoid exposure to sun light 7. CNS disease

Pregnancy
Contraindicated

Breast Feeding
Contraindicated

Old Age
Use with caution

Children
Contraindicated

Indications
1.Sinusitis 2.Bronchitis 3.Pneumonia 4.Urinary tract infection 5.Traveler`s diarrhoea 6.Skin and soft tissue infections

Dosage
Adults: Dose is determined on the basis of severity of the infection, type of infecting organism, age, weight and renal function of the patient. Sinusitis, Bronchitis, Pneumonia, Skin and soft tissue infections: 500 mg daily for 1 – 2 week Urinary tract infection: 250 mg / day for 10 days Traveler`s diarrhoea: 500 mg / day along with Loperamide

Schedule
H

Storage
Store at 25 – 30 degree C in a tightly closed container.

Over Dose
Give supportive measures and symptomatic treatment. Empty the stomach. Maintain appropriate hydration.