CISZINE-A

Mechanism of Action:

Ciszine-A (Cetirizine / Ambroxol) treats allergies by blocking histamine receptors and increasing the breakdown of mucus. It is produced by combining antihistamines with a systemic mucolytic agent. Cetirizine is classified as a second-generation antihistamine. It works by selectively inhibiting H1 histamine receptors. By preventing histamine from acting on its receptors, this drug helps reduce symptoms caused by hay fever or other allergies (such as a runny nose and watery eyes). Ambroxol has secretolytic properties, and it works by reducing the viscosity (thickness) of mucus, allowing it to remove more from the body.

Pharmacokinetic Properties:

Cetirizine is a potent and highly selective antagonist of peripheral histamine H1-receptor on effector cells in the GI tract, blood vessels, and respiratory tract.

Absorption: Rapidly absorbed from the GI tract (oral); Peak plasma concentrations after 1 hour. Rate of absorption absorbed by food, but not range.

Distribution: Enters into breast milk; Crosses the blood-brain barrier (insignificant volume). Protein-binding: Highly bound.

Excretion: in the form of urine (unchanged); 10 hours (elimination half-life).

Drug-Drug interactions:

Increased INR and risk of epistaxis when taken together with warfarin.

Potentially fatal: CNS depressant and anticholinergics may potentiate CNT depressant cetirizine.

Precautions:

1. If you have an allergic or hypersensitive reaction, seek emergency medical attention.

2. Possible symptoms include difficulty breathing, difficulty swallowing, swelling, chest tightness, skin rashes, and hives.

3. This medication should only be used as instructed and prescribed by your physician or pharmacist. Do not alter your dosage unless specifically instructed to do so by either of the above.

4. Dose and use often depend on the severity of the condition, as well as the patient’s medical history and current health status.

5. Before you start using this medicine, make sure that your doctor is aware of the following:

If you are pregnant or breastfeeding, If you have any allergy, If you have any other disease, disorder, or medical conditions, If you are using any other medicines or medicines, If you are using any vitamin or supplement.

Breastfeeding:

Contaminated; As Cetrizine and Ambroxol are contraindicated in breastfeeding; The combinations are contraindicated in the generic lactating mother.

Fertility: 

Limited data are available on human fertility, but no safety concerns have been identified. Animal data shows no safety concerns for humans. reproduction.

Dosage:

Ciszine-A (Cetirizine / Ambroxol) tablet is filtered and contains 5mg cetirizine and 60mg ambroxol. Your doctor will assess the severity of your symptoms when deciding on the correct dosage. After this, a dose can be prescribed to suit your individual needs. Always follow the dosing instructions given by your doctor and do not take more than the recommended dosage as it may endanger your health and safety.

Duration of action:

It is eliminated in the urine through an active transport mechanism. During a study of approximately 8.3.3 hours, cetirizine has a half-life of 6.5 to 10 hours in healthy adults. The duration of the action is at least 24 hours.

Adverse Reaction:

Heart disorders: severe hypotension, Gastrointestinal Disorders: Cholestasis, Nervous system disorders: extrapyramidal symptoms, myoclonus, orofacial dyskinesia, tick, Pregnancy, puparium, and perinatal condition: stillbirth, Kidney and urinary disorders: glomerulonephritis

Skin and subcutaneous tissue disorders: acute generalized exocrine inflammation (AGEP); Recurrence pruritus – pruritus within a few days after discontinuation of cetirizine, usually after prolonged use (eg, months to years).

Storage:

Store at 20-25°C

Overdosage:

Adults

5 to 10 mg orally once daily, depending on the severity of symptoms.

Geriatric Adults

5 to 10 mg orally once daily; A low dose of 5 mg once daily is the recommended dose for geriatric patients aged 77 years and older. Use the lowest effective dose. Elderly patients are more sensitive to anticholinergic effects. OTC labeling recommends patients over the age of 65 and older doctors ask before use.

Children and Adolescents 6 years and older

5 to 10 mg once daily, depending on the severity of symptoms.

Children 2 to 5 years

Chewable tablets are generally not recommended as initial therapy. The initial dose is 2.5 mg given once daily as a liquid formulation. If necessary, the dose may be increased to 5 mg once using chewable tablets.

Contraindictions:

Contaminated; Since Cetrizine and Ambroxol are contraindicated in pregnancy; Combinations are contraindicated in normal pregnancy.

Side effects:

• Patients treating allergies or any other medical condition with the drug. Ciszine-A (Cetirizine / Ambroxol) may experience some side effects. Contact your doctor if this happens. Some examples are listed here:
• Headache, Digestive upset, Dry feeling inside the mouth, Sore throat discomfort, Feeling of tiredness or sleeplessness

Although the occurrence of serious side effects is not considered common, patients still need to make themselves aware of the fact that it can occur in rare cases. If you notice abnormally hyperactive behavior, tremors, visual disturbances, or any other serious side effects, attend the emergency room or consult your doctor directly.

Warnings:

Avoid alcohol, sedatives, and tranquilizers due to increased risk of drowsiness, CNS may cause depression; Avoid activities requiring mental alertness until addicted to the drug, Use caution in liver and kidney weakness, The elderly may be more susceptible to adverse effects.

Pregnancy: 

There are no adequate and well-controlled studies on pregnant women.